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In humans for example, the skin located under the eyes and around the eyelids is the thinnest skin in the body at 0.5 mm thick, and is one of the first areas to show signs of aging such as "crows feet" and wrinkles.The skin on the palms and the soles of the feet is 4 mm thick and is the thickest skin on the body.Other animal coverings, such as the arthropod exoskeleton, have different developmental origin, structure and chemical composition.The adjective cutaneous means "of the skin" (from Latin cutis, skin).For example, hyaluronan, versican and decorin are present throughout the dermis and epidermis extracellular matrix, whereas biglycan and perlecan are only found in the epidermis.

For example, a frog sitting in an anesthetic solution would be sedated quickly, as the chemical diffuses through its skin. The epidermis is composed of the outermost layers of the skin.

Amphibian skin plays key roles in everyday survival and their ability to exploit a wide range of habitats and ecological conditions.(See also: image rotating (1.1 mb)) Optical coherence tomogram of fingertip, depicting stratum corneum (~500 µm thick) with stratum disjunctum on top and stratum lucidum (connection to stratum spinosum) in the middle. It forms a protective barrier over the body's surface, responsible for keeping water in the body and preventing pathogens from entering, and is a stratified squamous epithelium, Keratinocytes in the stratum basale proliferate through mitosis and the daughter cells move up the strata changing shape and composition as they undergo multiple stages of cell differentiation to eventually become anucleated.

During that process, keratinocytes will become highly organized, forming cellular junctions (desmosomes) between each other and secreting keratin proteins and lipids which contribute to the formation of an extracellular matrix and provide mechanical strength to the skin.

It also contains the hair follicles, sweat glands, sebaceous glands, apocrine glands, lymphatic vessels and blood vessels.

The blood vessels in the dermis provide nourishment and waste removal from its own cells as well as for the epidermis.

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This is named for its fingerlike projections called papillae that extend toward the epidermis.

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